4-Methoxycinnamic acid

4-Methoxycinnamic acid - Names and Identifiers

Name	4-METHOXYCINNAMIC ACID
Synonyms	4-METHOXYCINNAMIC ACID 4-Methoxycinnamic acid (E)-4-Methoxycinnamic acid trans-4-MethoxyClnnamic acid p-Methoxy-trans-cinnamic acid 4-Methoxy-trans-cinnamic acid
CAS	943-89-5
EINECS	213-405-4
InChIKey	AFDXODALSZRGIH-QPJJXVBHSA-N

4-Methoxycinnamic acid - Physico-chemical Properties

Molecular Formula	C10H10O3
Molar Mass	178.18
Density	1.195±0.06 g/cm3(Predicted)
Melting Point	173.5 °C(lit.)
Boling Point	342.6±17.0 °C(Predicted)
pKa	4.60±0.10(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
MDL	MFCD00004398

4-Methoxycinnamic acid - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection
WGK Germany	3
RTECS	UD3391300
FLUKA BRAND F CODES	8
TSCA	Yes
Hazard Class	IRRITANT

4-Methoxycinnamic acid - Upstream Downstream Industry

Raw Materials	2-Propen-1-one, 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-, (2E)- 4-METHOXYCINNAMYLALCOHOL TRANS-2-(4-METHOXYPHENYL)- 4-METHOXYBENZENEDIAZONIUM TETRAFLUOROBORATE 4-Methoxystyrene Diethylamine p-Anisaldehyde carbon monoxide CARBON DIOXIDE 4-Iodoanisole
Downstream Products	Ethyl 4-methoxycinnamate 7-Methoxy-isoquinolin-1(2H)-one 3-(4-METHOXYPHENYL)PROPIONYL CHLORIDE

4-Methoxycinnamic acid - Reference

Reference

1. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155

4-Methoxycinnamic acid - Nature

solubility	Soluble in ethanol, ethyl acetate and other organic solvents.
BRN	510468
NIST chemical information	2-Propenoic acid, 3-(4-methoxyphenyl)-, (e)-(943-89-5)
EPA chemical information	2-Propenoic acid, 3-(4-methoxyphenyl)-, (2E)- (943-89-5)

Last Update：2024-04-09 20:52:54

4-Methoxycinnamic acid - Uses and synthesis methods

p-methoxycinnamic acid sunscreen

At present, the most commonly used p-methoxycinnamic acid sunscreen agent is p-methoxycinnamate octyl, which is a colorless or light yellow liquid, insoluble in water, soluble in organic solvents such as ethanol and ethyl acetate, It has no irritation to the skin, has high safety in use, and has high ultraviolet absorption rate for UVB area, can effectively prevent 280-330mm ultraviolet rays, and has high absorption rate. It is; it can effectively prevent skin redness and sunburn. At present, this raw material is widely used in many sunscreen cosmetics in various countries. It is obtained by the reaction of p-methoxybenzaldehyde and malonic acid.

Preparation method

p-methoxybenzaldehyde was used as raw material, ammonium acetate was used as catalyst, microwave radiation technology was used, and p-methoxycinnamic acid was synthesized under solvent-free conditions through verta reaction.

biological activity

(E)-3-(4-Methoxyphenyl)acrylic acid (compound 3) can be separated from Arachis hypogaea,Scrophularia buergeriana Miquel,Aquilegia vulgaris,Anigozanthos preissii, etc. (E)-3-(4-Methoxyphenyl)acrylic acid has significant liver protective activity, anti-amnesia, enhancing cognitive activity, lowering blood sugar and neuroprotective activity.

Last Update：2024-04-09 01:59:50